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Defensins description
Human neutrophil defensins (alpha-defensins) belong to the family of cationic trisulfide-containing microbicidal peptides. Azurophilic granules of neutrophils contain Human Neutrophil Peptide (HNP) 1-4 which are highly homologous. The three principal human defensins, HNP 1-3 account for about 99 of the total defensin content of these cells. Besides neutrophils also B cells, T (CD8) cells, NK cells, monocyte/macrophages, epithelial cells produce alpha-defensins. Alpha-defensins exert next to microbicidal activity also chemotactic, immunomodulating, and cytotoxic activities and participate in host defense and inflammation. More recent the antiviral activity of several defensins was discovered. Alpha-defensins-1, -2 and -3 (HNP 1-3) are considered to contribute to the anti-HIV-1 activity of CD8 antiviral factor, findings that open new opportunities to HIV research.
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Antimicrobial peptides » Defensins
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Quantity
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Application
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Cat #
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HNP1-3, Human, ELISA kit
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2 x 96
det.
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HK317-02
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Defensin 5, Human, mAb 8C8
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0.5
mg
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F IA W
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HM2228-IA
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Defensin 5, Human, mAb 8C8
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100
µg
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F IA W
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HM2228
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HNP1-3, Human, ELISA kit
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1 x 96
det.
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HK317-01
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HNP1-3, Human, mAb D21
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100
µg
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F FC FS IA IF IP P W
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HM2058
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HNP1-3, Human, mAb D21, biotinylated
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50
µg
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F FC FS IA IF IP P W
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HM2059
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HNP1-3, Human, Natural
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>100
µg
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HC4014
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Neutrophil defensin 5, Rabbit, mAb R3
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100
µg
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F FC IA P W
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HM4008
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For research purposes only. Not
for drug, diagnostic or other use.
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F
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Frozen sections
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FC
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Flow cytometry
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FS
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Functional studies
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IA
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Immuno assays
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IF
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Immuno fluorescence
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IP
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Immuno precipitation
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P
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Paraffin sections
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W
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Western blot
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