Neutrophil proteins description

Neutrophils generate an arsenal of proteins with antimicrobial activities among which alpha-defensin 1-3, lactoferrin, calprotectin (S100A8/S100A9), PMN-elastase, lysozyme and myeloperoxidase (MPO). All of these proteins are produced in significant amounts by inflammatory cells and can be detected not only in plasma, but also in feces. In fact, high fecal neutrophil proteins levels have been detected in IBD patients and may be used as surrogate markers of active disease. Particularly lactoferrin and calprotectin, have been demonstrated to be useful in detecting active inflammatory bowel disease, in predicting recurrence of disease after surgery or monitoring the effects of medical therapy. Calprotectin and lactoferrin are remarkably stable and easily detectable in stool using ELISA. They appear to be equally recommendable as inflammation markers in the lower gastrointestinal tract especially in IBD patients.

 
Antimicrobial peptides » Neutrophil proteins Quantity Application Cat #
LBP, Human, Peptide 100 µg HC4030-01
MPO, Rat, ELISA kit 1 x 96 det. HK105-01
MPO, Mouse, ELISA kit 1 x 96 det. HK210-01
LBP, Human, ELISA kit 1 x 96 det. HK315-01
Elastase, Human, ELISA kit 1 x 96 det. HK319-01
LL-37, Human, ELISA kit 1 x 96 det. HK321-01
Arginase I, Human, ELISA kit 1 x 96 det. HK322-01
Arginase I, Human, ELISA kit 2 x 96 det. HK322-02
MPO, Human, ELISA kit 1 x 96 det. HK324-01
Calprotectin, Human, ELISA kit 1 x 96 det. HK325-01
NGAL, Human, ELISA kit 1 x 96 det. HK330-01
Neutrophils, Mouse, mAb NIMP-R14 100 µg F FC FS IA P HM1039
Neutrophils, Mouse, mAb NIMP-R14, biotinylated 50 µg F FC FS IA P HM1039BT
Neutrophils, Mouse, mAb NIMP-R14, FITC 100 µg F FC FS IA P HM1039F
S100A9, Mouse, mAb MU14-2A5 0.5 mg F FS IA IF P W HM1102-IA
SLPI, Human, mAb 31 0.5 mg F IA IP P W HM2037-IA
LL-37/CAP-18, Human, mAb 3D11 0.5 mg FS IF P W HM2070-FS
MPO, Human, mAb 266-6K1 0.5 mg IA W HM2164-IA
Elastase, Human, mAb 265-3K1 0.5 mg IA W HM2174-IA
MRP-8, Human, mAb 7C12/4 100 µg FC IA W HM2175
MRP-14, Human, mAb 1H9 100 µg FC IA W HM2176
MPO, Rat, mAb 2D4 0.5 mg F FC IA IF HM3030-IA
Lactoferrin, Bovine, mAb a-bC-lobe 100 µg IA W HM4013
BPI, Human, ELISA kit 2 x 96 det. HK314
BPI, Human, mAb 3F9 100 µg IA HM2041
BPI, Human, mAb 4E3 100 µg FC FS IA HM2170
BPI, Human, mAb 4H5 100 µg IA HM2042
BPI, Human, pAb 100 µg IA IP HP9022
Calprotectin, Human, ELISA kit 2 x 96 det. HK325-02
Calprotectin, Human, mAb 27E10 100 µg F FC IA IP P W HM2156
Calprotectin, Human, mAb 27E10, biotinylated 50 µg F FC IA P W HM2156BT
Calprotectin, Human, mAb 27E10, FITC 100 µg F FC IA P W HM2156F
CRISP-3, Human, pAb 100 µg IA P W HP9033
Elafin (Trappin-2), Human, ELISA kit 2 x 96 det. HK318
Elafin, Human, Recombinant 50 µg HC4011
Elastase, Human, ELISA kit 2 x 96 det. HK319-02
Elastase, Human, mAb 265-3K1 100 µg IA W HM2174
Elastase, Human, pAb 100 µg IA HP9027
Lactoferricin, Bovine, mAb 5F12.1.2 100 µg IA W HM4012
Lactoferrin, Bovine, pAb 100 µg IA IP W HP7001
Lactoferrin, Human, ELISA kit 2 x 96 det. HK329
Lactoferrin, Human, mAb 265-1K1 100 µg F IA W HM2173
Lactoferrin, Human, pAb 100 µg IA IP W HP9034
LBP, Human, Purified, Natural 10 µg HC4010
LL-37, Human, ELISA kit 2 x 96 det. HK321-02
LL-37/CAP-18, Human, mAb 1-1C12 100 µg IA IF P W HM2071
LL-37/CAP-18, Human, mAb 3D11 100 µg FS IF P W HM2070
LL-37/CAP-18, Human, Peptide 50 µg HC4013
Lysozyme, Human, pAb 100 µg IA IP W HP9035
MPO, Human, ELISA kit 2 x 96 det. HK324-02
MPO, Human, mAb 266-6K1 100 µg IA W HM2164
MPO, Human, mAb 266-6K1, biotinylated 50 µg IA W HM2164BT
MPO, Human, mAb 266-6K1, FITC 100 µg IA W HM2164F
MPO, Mouse, ELISA kit 2 x 96 det. HK210-02
MPO, Mouse, mAb 8F4 100 µg F FC IA HM1051
MPO, Mouse, mAb 8F4, biotinylated 50 µg F FC IA HM1051BT
MPO, Mouse, mAb 8F4, FITC 100 µg F FC IA HM1051F
MPO, Rat, ELISA kit 2 x 96 det. HK105-02
MPO, Rat, mAb 2D4 100 µg F FC IA IF HM3030
MPO, Rat, mAb 2D4, biotinylated 50 µg F FC IA IF HM3030BT
MPO, Rat, mAb 2D4, FITC 100 µg F FC IA IF HM3030F
NGAL, Human, ELISA kit 2 x 96 det. HK330-02
NGAL, Human, mAb 697 100 µg IA IF HM2193
Proteinase 3, Human, mAb PR3-G2 100 µg F FC IA W HM2172
Proteinase 3, Human, mAb PR3-G2, FITC 100 µg F FC IA W HM2172F
Proteinase 3, Human, mAb WGM2 100 µg F FC FS IA P W HM2171
Proteinase 3, Human, mAb WGM2, FITC 100 µg F FC IA W HM2171F
SLPI, Human, ELISA kit 2 x 96 det. HK316
Calprotectin, Human, recombinant 50 µg FS HC2120
LBP, Human, Peptide 0.5 mg HC4030-05
LBP, Human, Peptide 1 mg HC4030-10
LBP, Human, ELISA kit 2 x 96 det. HK315-02
Neutrophils, Mouse, mAb NIMP-R14, R-PE labeled 100 tests F FC FS IA P HM1039PE-100
Neutrophils, Mouse, mAb NIMP-R14, R-PE labeled 25 tests F FC FS IA P HM1039PE-25
S100A9, Mouse, mAb MU14-2A5 100 µg F FS IA IF P W HM1102
S100A9, Mouse, mAb MU14-2A5, Biotin 50 µg F FS IA IF P W HM1102BT
SLPI, Human, mAb 31 100 µg F IA IP P W HM2037
SLPI, Human, mAb 31, biotinylated 50 µg F IA P W HM2038
SLPI, Human, pAb 100 µg IA IP W HP9024
 
For research purposes only. Not for drug, diagnostic or other use.

F Frozen sections
FC Flow cytometry
FS Functional studies
IA Immuno assays
IF Immuno fluorescence
IP Immuno precipitation
P Paraffin sections
W Western blot