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FABP, mouse/rat description
Highly sensitive measurement of cytosolic proteins allows early and rapid detection of loss of cell membrane integrity. Small-unbound cytosolic proteins show a rapid release from damaged cells. The detection of cell damage is of importance in cellular toxicology studies and in various experimental and clinical situations. Examples of the latter are myocardial infarction and liver transplantation. The family of Fatty Acid Binding Proteins (FABP) with tissue specificity with a molar mass of 14 kDa has been found to be very useful for this purpose. Ischemically damaged tissues release FABP rapidly enabling early detection of ischemically damaged organs. Further ischemically damaged organs are characterized histologically by (near) absence of FABP facilitating recognition of such areas. Various types of FABP have been detected: Heart FABP (primarily present in heart and striated muscle cells but also of interest as brain damage marker), Liver FABP (present in liver and proximal small intestine), Intestinal FABP (present in small bowel epithelium), Adipocyte-FABP, Brain-FABP, Epidermal-FABP, Ileal-FABP (ILBP) and Myelin-FABP. HB provides antibodies to all FABPs and sensitive immunoassays for Heart-FABP, Liver-FABP and Intestinal-FABP.
For research purposes only. Not
for drug, diagnostic or other use.
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F
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Frozen sections
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FC
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Flow cytometry
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FS
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Functional studies
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IA
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Immuno assays
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IF
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Immuno fluorescence
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IP
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Immuno precipitation
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P
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Paraffin sections
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W
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Western blot
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