Technical datasheet
Description
Ficolins are a group of proteins containing both a collagen-like domain and a fibrinogen-like domain. They are found in various tissues. The domain organizations between ficolins and mannose binding lectin (MBL) are similar, although the carbohydrate-binding moieties are different. In man two types of ficolins (L-ficolin/P35 and H-ficolin) are present in serum and one type (M-ficolin) in cells. H-ficolin (also Hakata antigen or ficolin H) is produced by the liver and by the lung. H-ficolin is associated with three types of MASPs and sMAP, this complex activates C4, C2 and C3 in the fluid phase.
Formulation
1 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS, containing 0.02% sodium azide and 0.1% bovine serum albumin.
Species
Mouse IgG1
Application
The antibody can be used for immuno precipitation and immuno assays.
Storage and stability
Product should be stored at 4°C. Under recommended storage conditions, product is stable for one year.
References
- Matsushita, M et al; Activation of the lectin complement pathway by ficolins. Int Immunopharmacol 2001,
1: 359
- Matsushita, M et al; Activation of the lectin complement pathway by H-ficolin (Hakata antigen). J of Immunol 2002, 168: 3502
- Matsushita, M et al; The role of ficolins in innate immunity. Immunobiol 2002, 205: 490
- Kuraya, M et al; Expression of H-ficolin/Hakata antigen, mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 by human glioma cell line T98G. Int Immunol 2003, 15: 109
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result with the use of or derivation of this product.
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