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CD56, Human, mAb NKI-nbl-1

Catalog #: HM2133

Quantity: 100 µg

Availability: In stock

Description: CD56, Human, mAb NKI-nbl-1

CD56 is an isoform of the Neural Cell Adhesion Molecule (NCAM). CD56 is an adhesion molecule involved in intercellular homophilic adhesion and plays a role in outgrowth of neurites and the development of the nervous system. Furthermore CD56 is a marker for natural killer cells and found in various tumors. Several isoforms of NCAM have been identified: two transmembrane isoforms of 140 and 180 kD, a GPI-linked isoform of 120 kD which lacks a transmembrane domain and a fourth variant which is leading to the expression of a soluble form (sNCAM). Antibody NKI-nbl-1 recognizes the transmembrane glycoprotein of 140 and 180 kD.

Specifications

Catalog number HM2133
Product type Monoclonal antibodies
Quantity 100 µg
Formulation 1 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS, containing 0.02% sodium azide and 0.1% bovine serum albumin.
Application F, FC
Use For flow cytometry and immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.
Isotype Mouse IgG1
Species Human
References 1. Moolenaar, C et al; Expression of neural cell adhesion molecule-related sialoglycoprotein in small cell lung cancer and neuroblastoma cell lines H69 and CHP-212. Cancer Res 1990, 50: 1102
2. Lee, B et al; Quantification of CD4, CCR5 and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages. Proc Natl Acad Sci 1999, 96: 5125
3. Sharron, M et al; Expression and coreceptor activity of STRL33/Bonzo on primary peripheral blood lymphocytes. Blood 2000, 96: 41
4. Feng, M et al; Development of human lymphohematopoietic stem and progenitor cells defined by expression of CD34 and CD81. Blood 2001, 97: 3755
5. Reich, K et al; Engagement of the Fc epsilon RI stimulates the production of IL-16 in Langerhans cell-like dendritic cells. J Immunol 2001, 167: 6321
6. Perin, E et al; Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 2003, 107: 2294
Storage and stability Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
Precautions For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result with the use of or derivation of this product.
Disease Tumor immunology