New Human Complement Factor D ELISA

Wednesday - November 24, 2010

New Human Complement Factor D ELISA

Hycult Biotech presents a highly sensitive and specific assay for the quantitation of factor D (Cat.# HK343).

Special features:
Factor D occurs in plasma as an active enzyme and is the rate-limiting protease of the alternative complement pathway. It has both the lowest plasma concentration (1.05 ± 0.27 µg/ml) and the lowest molecular weight (24kDa) of all complement components. Assays for the quantitation of factor D therefore need to be highly sensitive and specific.

• Reliable and fast technique based on highly specific antibodies for human factor D
• Quantitative measurement in serum, plasma and urine
• Measurable concentration 0.078– 10 ng/ml
• Detection limit 0.078 ng/ml

Factor D is synthesized as a precursor single-chain molecule. Factor D is highly specific and cleaves factor B bound to C3b, generating the C3bBb enzyme. It is the rate-limiting C3 convertase enzyme of the alternative pathway.

Factor D and disease
In normal human subjects, factor D is rapidly eliminated via the kidney. In patients with renal failure, plasma and urine levels of factor D are elevated. Elevated plasma levels returned to normal levels within seven days after successful renal transplantation.

Available reagents for factor D related research:

Cat. No.	Product
HM2258	Complement factor D, Human, mAb D10/4
HM2259	Complement factor D, Human, mAb I8/1
HM2072	C3/C3b, Human, mAb 755
HM2168	Activated C3, Human, mAb bH6
HK342	Complement factor H, Human, ELISA

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