Coming soon: Human Properdin ELISA
Monday - January 23, 2012
The human Properdin ELISA (Cat.# HK334) can be used for the determination of properdin in serum, plasma, urine, BAL and CSF.
Detection of human properdin in normal human plasma
A panel of 30 plasma samples from randomly selected healthy donors (males and females) was tested for human properdin. The average level of human properdin was 24µg/ml, with a range of 15-36µg/ml, corresponding to previously reported levels.
Properdin and diseases
- Deficiency or malfunction of properdine may lead to severe impairment of alternative pathway activation, depending on the precise nature of the defect. One parameter of functional defect in the presence of measurable levels of protein is an impaired generation of the more active tetramer and trimer forms.
- Properdin-deficient individuals are shown to be more vulnerable for meningococcal as well as non-meningococcal infections
- Properdin deficiency might also contribute to autoimmunity due to its role in safe clearance of apoptotic and/or necrotic cells
- Properdin deficiency can be divided in three phenotypes:
- Type 1, properdin is absent in plasma
- Type 2, strongly reduced levels (1-10% of normal levels)
- Type 3, normal levels but inactive properdin
- Properdin is likely to contribute to development of abdominal aortic aneurysms (AAA) by causing chronic inflation of the vascular wall
- In chronic kidney disease (CKD) unwanted complement activation is observed and properdin was shown to be present in diseased but not in normal kidney tissue.
Specifications
- Working time of 3½ hours.
- Minimum concentration which can be measured is 0.31 ng/ml.
- Measurable concentration range of 0.31 to 20 ng/ml.
- Working volume of 100 µl/well.
- Useful for serum, plasma, urine, BAL and CSF samples
- Cross reactivity with mouse, pig and rabbit
For more information have a look at the poster of properdin or contact us at support@hycultbiotech.com
Low Endotoxin Antibodies for Functional Studies Read this article » BSA-free Antibodies for Immuno Assays Read this article » Now available: 1-plate assays! Read this article » Special Formulations and Service Read this article » 2012 Hycult Biotech Catalog Read this article » Discounts for Publication References Read this article » Government Accounts Read this article » American Assoc. of Immunology Meeting Read this article » Human Properdin ELISA and mAbs Read this article » Immuno Assay mAbs Read this article » Single-Plate ELISAs Read this article » Functional Study, Low Endotoxin mAbs Read this article » Upgrade I-FABP ELISA (Cat.#HK406) Read this article » Nate: Hycult Biotech's Mascot Read this article » Visit us at MEDICA Read this article » New R-PE monoclonals available Read this article » Hycult Biotech Inc Bronze Sponsor SLB Read this article » NEW product: Human CRP ELISA Read this article » Hycult Biotech Gold Sponsor EMCHD 2011 Read this article » Discount Human LBP ELISA and Human sCD14 ELISA Read this article » Variant-specific quantification of factor H Read this article » Increased Exposure to Bacterial Antigen RpL7/L12 Read this article » IgG glycan hydrolysis Read this article » Differential role of the lectin pathway Read this article » C1q deficiency linked to autoimmune disorders Read this article » New Complement Proteins available Read this article » Formation of Hycult Biotech Inc. Read this article » PTX3, a biomarker for vascular inflammation Read this article » New Human Complement Factor D ELISA Read this article » Unique ELISA to elucidate the role of human MASP-3 Read this article » Mast cells, basophils and eosinophils Read this article » Unique antibodies for functional studies Read this article » C1q product release Read this article » Human SAA ELISA Read this article »