Technical datasheet
Description
The monoclonal antibody PNL2 recognises a melanocyte associated antigen. The antigen recognised by PNL2 is chemically resistant and thus allows immunostaining after bleaching or decalcification. PNL2 stains only melanocytic lesions, clear cell sarcoma, melanotic schwannome, angiomyolipoma and lymphangioleiomyomatosis. The antibody PNL2 has the same specificity as anti Melan A and HMB-45 antibodies. However PNL2 staining is stronger and more consistent. The antigen recognised by PNL2 is different from Melan A and gp100.
Formulation
1 ml culture medium containing 0.02% sodium azide
Species
Mouse IgG1
Application
The monoclonal antibody PNL2 can be used for Western blotting, immuno precipitation and immunohistology on frozen and paraffin sections.
Use
For immunohistology and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.
Storage and stability
Product should be stored at 4°C. Under recommended storage conditions, product is stable for one year.
References
1. Rochaix, P et al; PNL2, a new monoclonal antibody directed against a fixative-resistant melanocyte antigen. Mod Pathol 2003, 16: 481
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result with the use of or derivation of this product.
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References
1. Rochaix, P et al; PNL2, a new monoclonal antibody directed against a fixative-resistant melanocyte antigen. Mod Pathol 2003, 16: 481