Technical datasheet
Description
Syntrophin-associated serine/threonine kinase-124 (SAST-124) is a signalling molecule belonging to the microtubule-associated serine/threonine kinases. They have a unique structural feature with a serine/threonine kinase domain and a postsynaptic density protein-95/discs large/zona occludens-1 domain. SAST-124 is a signalling protein that binds to syntrophin, an adaptor protein that connects signalling molecules to the dystrophin-associated protein complex.
SAST-124 is expressed in neurons of the subventricular zone and granule cells of the olfactory bulb, Islands of Calleja, hippocampal dentate gyrus and cerebellum. SAST-124 is selectively expressed in the nuclei of neurons. SAST-124 has a role in transcriptional regulation in the adult stem cells and their progeny cells in brain.
SAST-124 is also located in glia-like small cells of the corpus callosum and the trigeminal ganglion cells indicating a function other than transcriptional regulation.
Formulation
1 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS, containing 0.02% sodium azide and 0.1% bovine serum albumin.
Species
Mouse IgG1
Application
The antibody can be used for Western blotting and immunoprecipitation. Furthermore the antibody is useful for immunohistology for frozen sections and immuno assays.
Use
For Western blotting and immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.
Storage and stability
Product should be stored at 4°C. Under recommended storage conditions, product is stable for one year.
References
1. Yano, Y et al; SAST124, a novel splice variant of syntrophin-associated serine/threonine kinase (SAST), is specifically localized in the restricted brain regions. Neuroscience 2003, 117: 373
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result with the use of or derivation of this product.
Also available
References
1. Yano, Y et al; SAST124, a novel splice variant of syntrophin-associated serine/threonine kinase (SAST), is specifically localized in the restricted brain regions. Neuroscience 2003, 117: 373