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SPLUNC1, Human, mAb 5F5G1

Catalog #: HM2315

Quantity: 100 µg

The monoclonal antibody 5F5G1 recognizes SPLUNC1. The human genome encodes eight different PLUNC (palate, lung, and nasal epithelium associated) proteins that share a predicted structural similarity. The 25 kDa SPLUNC1/BPIFA1 protein was the first identified PLUNC protein and is secreted in human sputum and tracheobronchial secretions, as well as in saliva, nasal lavage fluid, and in specific granules of human neutrophils.

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Description: SPLUNC1, Human, mAb 5F5G1

The monoclonal antibody 5F5G1 recognizes SPLUNC1. The human genome encodes eight different PLUNC (palate, lung, and nasal epithelium associated) proteins that share a predicted structural similarity. The 25 kDa SPLUNC1/BPIFA1 protein was the first identified PLUNC protein and is secreted in human sputum and tracheobronchial secretions, as well as in saliva, nasal lavage fluid, and in specific granules of human neutrophils. The biological function of SPLUNC1/BPIFA is not known, but structural similarities to BPI family proteins suggest that SPLUNC1/BPIFA may be involved in defense responses in the airways. This proposed function is supported by the finding that SPLUNC1 levels are elevated in chronic airway inflammation and that mice overexpressing SPLUNC1/BPIFA exhibit enhanced protection against P. aeruginosa. Moreover, the protein was reported to bind LPS and shown to play and essential role in pulmonary host defense against Klebsiella pneumoniae respiratory infection. The monoclonal antibody, 5F5G1, is specific for SPLUNC1/BPIFA and can be used for ELISA, western blot and immunohistochemistry.

Specifications

Catalog number HM2315
Product type Monoclonal antibodies
Quantity 100 µg
Formulation 1 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide
Application F, IA, IF, W
Use For immunohistochemistry, immuno assay, immunofluorescence and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
Immunogen Recombinant SPLUNC1
Isotype Mouse IgG1
Species Human
Alias LUNX, NASG, PLUNC, BPI fold-containing family A member 1, SPURT, Lung-specific protein X, Nasopharyngeal carcinoma-related protein, Palate lung and nasal epithelium clone protein, Secretory protein in upper respiratory tracts, Short PLUNC1, Tracheal epithelium-enriched protein, Von Ebner protein Hl
Positive Control Lung epithelium
References 1.Gakhar, L et. Al. PLUNC is a novel airway surfactant protein with anti-biofilm activity. PLoS One 2010, 5(2): e9098
Storage and stability Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
Precautions For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product
Disease Pulmonology, Tumor immunology