Description: MASP-2/MAp19, Human, mAb 6G12, immuno assay antibody
The monoclonal antibody 6G12 reacts with high affinity to the N-terminal end of MASP-2 and Map19.
|Product type||Monoclonal antibodies|
|Formulation||0.5 mg of 0.2 μm filtered protein G purified antibody solution in PBS (exact concentration is indicated on the label).|
|Application Notes||IA: the antibody can be used as detection antibody.
W: Both reduced and non-reduced can be performed. The expected band size for MASP-2 is approximately 75 kDa and for Map19 approximately 20 kDa.
|Use||Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.|
|References||1. Moller-Kristensen, M et al; Levels of mannan-binding lectin-associated serine protease-2 in healthy individuals. J Immunol 2003, 282: 159
2. Krarup, A et al; L-ficolin Is a Pattern Recognition Molecule Specific for Acetyl Groups*. JBC 2004, 46: 47513
3. Ameye, L et al; M-ficolin levels are associated with the occurrence of severe infections in patients with haematological cancer undergoing chemotherapy. Clin Exp Imm 2011, 167:303
4. Zacho, R et al; Studies of the Pattern Recognition Molecule H-ficolin. JBC 2012, 11: 8071
5. Damgaard Sandahl, T et al; The lectin pathway of the complement system is downregulated in Crohn's disease patients who respond to anti-TNF-α therapy. J Crohn Col 2013, 8:521
6. Man-Kupisinska, A et al; A New Ligand-Based Method for Purifying Active Human Plasma-Derived Ficolin-3 Complexes Supports the Phenomenon of Crosstalk between Pattern-Recognition Molecules and Immunoglobulins. PLoS ONE 2016, 11: e0156691
|Storage and stability||Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.|
|Precautions||For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result with the use of or derivation of this product.|