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CpG- oligonucleotides description
The vertebrate immune system has evolved innate immune defense pattern recognition receptors (PRRs) that detect unmethylated cytosine-phosphate-guanine (CpG) motifs within bacterial DNA. Cellular activation by CpG motifs occurs via the Toll signal pathway. TLR9 appears to be a major component of the CpG-DNA receptor, acting by direct binding to CpG-DNA, which triggers the induction of cell signaling pathways, leading to stimulation of various cells of the immune system. Optimal sequences for activating TLR9 vary among species. Different classes of CpG ODN are characterized each with distinct effects on the immune response: CpG-A ('D'-type), CpG-B ('K'-type), and CpG-C.
For research purposes only. Not
for drug, diagnostic or other use.
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F
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Frozen sections
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FC
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Flow cytometry
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FS
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Functional studies
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IA
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Immuno assays
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IF
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Immuno fluorescence
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IP
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Immuno precipitation
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P
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Paraffin sections
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W
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Western blot
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