Azurocidin in bacterial infections and acute care
Azurocidin, also known as heparin binding protein (HBP) or CAP37, is a specific chemoattractant for monocytes and an important inflammatory mediator. This protein is a member of the serine protease gene family but it is not a serine proteinase itself. As a potent inducer of vascular permeability, it is known to be a good predictor for the risk of developing sepsis with circulatory collapse. Other studies have demonstrated its usefulness in urinary tract infection, Acute Respiratory Distress Syndrome (ARDS), organ failure after cardiac arrest and acute pyelonephritis. A 2015 study has also attributed antibacterial and wound-healing properties to CAP37. This underlines the relevance of azurocidin as a marker in an acute care environment.
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