C3c, a multi-organ marker
The human C3C ELISA is highly specific for a neoepitope which is found exclusively on C3c. The disadvantage of most complement biomarkers is their short half-life, making reliable sample collection and measurements difficult. Unlike other C3 fragments, C3c does not bind to other structures or plasma proteins and appears in the fluid phase only. This makes C3c a reliable and useful biomarker that can be used for a variety of inflammatory and autoimmune conditions.
Older studies have already established a connection between C3c with Alzheimer’s dementia, Parkinson’s disease and ALS (amyotrophic lateral sclerosis). A recent article has shown a significant reduction of C3c in patients who underwent laparoscopic gastric bypass. This implies that C3c may be a marker of the chronic inflammatory process underlying insulin resistance. Lower C3c levels are also associated with glomerulonephritis. It is a sign of activated alternative complement pathway and is therefore associated with improved survival in patients with heart failure. Consequently, C3c is a complement marker involved in a range of pathological conditions, making it a relevant target for many furture scientific investigations.
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