EndoCAb and the microbiota-gut-brain axis
The EndoCAb® ELISA has been developed for determination of endotoxin core antibodies in median units per ml. Endotoxin core antibodies play an important role in the clearance of pathogens in both disease and medical interventions. Where the LAL assay is a direct readout of endotoxin concentration and LBP is more an acute phase protein, circulating levels of endotoxin core antibodies can demonstrate the capability of an organism to fight off endotoxins as a pathogen.
A study in 2006 has shown that decreased preoperative levels of EndoCAb is a significant predictor of long-term mortality in patients that are undergoing cardiac surgery. Recent publications have also shown its usefulness in microbial translocation, HIV and chronic endotoxemia. A recent article has even identified EndoCAb as a significant predictor of lower cognitive processing speed in heavy-drinking men living with HIV. All these insights combined demonstrate that EndoCAb is of relevance for any condition that is related to the microbiota-gut-brain axis.
The exclusively available EndoCAb ELISA kit is available in different formats: IgA, IgG and IgM. The HK504 contains all isotypes and one plate. The HK504-AGM contains one plate of each isotype. The different versions allow flexibility for pre-screening of a cohort or for setting up initial experiments.
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