CHIPS (Chemotaxis Inhibiting Protein of Staph. aureus)
The bacterial pathogen Staphylococcus aureus is insensitive to antimicrobial host defense peptides such as defensins, protegrins, platelet microbicidal proteins and bacteriocins. Staphylococci have developed various resistance mechanisms including those specific for bacteriocins and several host defense peptides. A protein belonging to the resistance mechanism of Staphylococcus aureus is known as CHIPS (Chemotaxis Inhibiting Protein of Staphylococcus aureus). CHIPS is a protein produced by Staphylococcus aureus that inhibits chemotaxis of neutrophils by blocking the Formyl Peptide Receptor (FPR) and C5a Receptor on neutrophils. CHIPS and antibodies against CHIPS can be useful for various experimental infection models of Staphylococcus aureus. Furthermore these reagents can be of help in studies on the role of FPR and C5a in inflammatory processes.
|Formulation||10 µg lyophilized, purified CHIPS. Reconstitute the vial by pipetting distilled or de-ionized water, volume depending on the concentration to be used.|
|Use||It is recommended that users test the reagent and determine their own optimal concentrations for biological studies.|
|Storage and stability||Lyophilized product should be stored at 4 °C. Store stock solution in aliquots at -70 °C. Repeated freeze and thaw cycles will cause loss of activity. Under recommended storage conditions, product is stable for one year.|
|Precautions||For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result with the use of or derivation of this product.|
|Use:||It is recommended that users test the reagent and determine their own optimal concentrations for biological studies.|