Tissue factor, Human, mAb CLB/TF-5

Catalog #: HM2346
Quantity: 100 µg
$332.00

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Description
Details
The monoclonal antibody clone CLB/TF-5 recognize human soluble tissue factor (also known as coagulation factor III, tissue thromboplastin or CD142). This protein activates the blood clotting system by binding to, and activating, the plasma serine protease, factor VIIa, following vascular injury. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Because of its essential role in hemostasis, tissue factor plays a role in pathology associated with hemostasis, triggering the coagulation system in many thrombotic diseases and the coagulopathies associated with sepsis and other forms of disseminated intravascular coagulation. Recent research has also implicated tissue factor in a variety of nonhemostatic roles, including cell signaling, inflammation, vasculogenesis, and tumor growth and metastasis.
Specifications

Specifications

Catalog number HM2346
Product type Monoclonal antibodies
Quantity 100 µg
Formulation 1 ml (100 μg/ml) 0.2 μm filtered protein A purified antibody solution in 20 mM TRIS, 150 mM NaCL, pH 8.0.
Isotype Mouse IgG1
Species Human
Alias Coagulation factor III, CD142, Thromboplastin
Storage and stability Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Precautions For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
Disease Cardiology and metabolism, Tumor immunology
Application
Applications
  • Application:
    FC, IA, W
  • Application Notes:
    FC: Antibody CLB/TFPI C-Terminus stains the extracellular domain of TFPI.
    W: A reduced sample treatment and SDS-Page was used. Human serum and plasma was used and bands of ~50 and 26kDa were found.
  • Use:
    Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions.
References
References
References:
1. Keller, T et al; Tissue factor serum levels and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk prospective population study. Journal of Thrombosis and Haemostasis 2006, 4: 2391
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