TFPI, Human, mAb CLB/TFPI C-terminus
Catalog #: HM2350
Quantity: 100 µg
TFPI is a serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. TFPI is known to interact and inhibit the activated factor X and VIIa-TF proteases in an autoregulatory loop. TFPI is a dual inhibitor, binding to the TF/FVIIa complex to prevent it from acting on its FIX and FX substrates, and by directly inhibiting FXa. Inadequate down-regulation of FXa function by TFPI deficiency leads to thrombosis. Besides coagulation, TFPI may play additional roles in innate immunity, microbial defense, inflammation, angiogenesis, lipid metabolism, and cellular signaling, proliferation, migration, and apoptosis.
|Product type||Monoclonal antibodies|
|Formulation||1 ml (100 μg/ml) 0.2 μm filtered protein A purified antibody solution in 20 mM TRIS, 150 mM NaCL, pH 8.0.|
|Alias||Tissue factor pathway inhibitor, Extrinsic pathway inhibitor|
|Storage and stability||Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.|
|Precautions||For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.|
|Disease||Autoimmunity, Cardiology and metabolism|
Application:FC, IA, W
Application Notes:FC: Antibody CLB/TFPI C-Terminus stains the extracellular domain of TFPI.
W: A reduced and non-reduced sample treatment was used. HEK293 lysate was used and bands of 55, 43 and 34kDa were found.
Positive Control:Endothelial and smooth muscle cells
Use:Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions.