Nectin-2, Human, clone TX31

Monoclonal antibody clone Tx31 recognizes human Nectin-2. Nectin-2 was initially discovered as a poliovirus receptor-related protein (PRR2).
Quantity:
100 µg
Catalog #:
HM2393-100UG

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Monoclonal antibody clone Tx31 recognizes human Nectin-2. Nectin-2 was initially discovered as a poliovirus receptor-related protein (PRR2). Nectins are immunoglobulin-like transmembrane cell adhesion molecules expressed in various cell types. The nectin family consist of 4 members. Nectin-1/2/3 are expressed in cells like fibroblast, epithelial cells and neurons. Nectin-2 is also expressed in hematopoietic cells and spermatids. Nectins, which are ca2+-independent immunoglobulin like molecules, regulate cell-cell adhesions. They are involved in different type of disease like viral infection, autism, Alzheimer and cancer. Nectin-2 is believed to form homodimers or heterodimers in their function for cell adhesion. It forms an immune costimulatory function together with DNAM-1 thereby regulating both NK and CTL function.
Specifications
Product type Monoclonal antibodies
Quantity 100 µg
Formulation 0.2 µm filtered in PBS+0.1%BSA
Application Flow cytometry, Functional studies, Western blot
Immunogen Recombinant protein
Isotype Mouse IgG1
Species Human
Alias CD112, Herpes virus entry mediator B, Herpesvirus entry mediator B, HveB, Nectin cell adhesion molecule 2, Poliovirus receptor-related protein 2.
References Tahara-Hanaoka, S et al; Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112). Jap Soc Immunol 2004, 16:533
Storage and stability Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Precautions For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
Disease Infectious diseases
Applications
Application: Flow cytometry, Functional studies, Western blot
Application notes: - W: the antibody can be used for reduced and non-reduced samples. The expected band size is 48 kDa.
- FS: anti-CD112 mAb partially inhibited CD226-Fc binding to the CD112 transfectant. It is of note that anti-CD155 and anti-CD112 (TX-31) mAb partially, rather than completely, inhibited the cytotoxicity, probably because these mAb incompletely blocked interaction of CD226 with the ligands (Ref.1).
References
References: Tahara-Hanaoka, S et al; Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112). Jap Soc Immunol 2004, 16:533