Lipid A, mAb 26-5

Quantity:
100 µg
Catalog #:
HM6009

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The monoclonal antibody 26-5 recognizes lipid A. The lipid A domain of lipopolysaccharide (LPS) is a unique, glucosamine-based phospholipid that makes up the outer monolayer of the outer membrane of most gram-negative bacteria.
Lipid A is responsible for the endotoxic activities of LPS, and a heteropolysaccharide. The heteropolysaccharide generally consists of an oligosaccharide termed the core region. This core region is in some bacterial families composed of repeating oligosaccharide units, the so-called O chain. The lipid A moiety of LPS is detected by the TLR4/MD2 receptor of the mammalian innate immune system. Picomolar levels of lipid A induce macrophages to synthesize potent mediators of inflammation, such as TNF-α and IL-1β. Furthermore, lipid A activates the production of costimulatory molecules required for adaptive immunity and stimulates tissue factor production in mononuclear and endothelial cells. All these events are desirable for clearing local infections.
Specifications
Product type Monoclonal antibodies
Quantity 100 µg
Formulation 1 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide.
Application Immuno assays
Isotype Mouse IgG2b
Species N/A
References Erich, T et al; Binding characteristics and cross-reactivity of three different antilipid A monoclonal antibodies. J of Immunol 1989, 143: 4053
Storage and stability Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
Precautions For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
Disease Infectious diseases
Applications
Application: Immuno assays
References
References: Erich, T et al; Binding characteristics and cross-reactivity of three different antilipid A monoclonal antibodies. J of Immunol 1989, 143: 4053
CoA-TDS HM4000-6000
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Protocol