Human EndoCab® ELISA, Human sCD14 ELISA, Human LBP ELISA and LAL chromogenic endpoint assay

Microbial translocation

In pathogenic HIV infections, the translocation of microbial products like LPS from the gastrointestinal tract to the circulation has been suggested as a major driver of chronic immune activation that is associated with disease progression. Increasing number of clinical observations suggest that microbial translocation might affect HIV disease progression, response to therapy and non-AIDS co morbidities.

Lipopolysaccharide (LPS), a component of Gram-negative bacterial cell walls and an agonist of Toll-like receptor 4 (TLR-4) (1), is considered a major marker of microbial translocation (2-4). In addition to local defense against microbial translocation at the level of the GI mucosa and within the liver…… Read more

Endotoxemia

Coronary artery disease (CAD) is being recognized as a chronic inflammatory disease (1). A high-fat meal induces low-grade endotoxemia (2) and the levels of endotoxin have been associated with a threefold risk of atherosclerosis (3). Furthermore, the levels of endogenous anti-endotoxin antibodies (EndoCab), LPS binding protein (LBP) and soluble CD14 (sCD14) were found to be important in determining the activity of endotoxin (4,5)…..Read more 

Enteropathy

The World Health Organization has set forth ambitious efforts to control, and where possible, eliminate the neglected tropical diseases (NTDs) that contribute to poverty and ‘‘impair the ability of those infected to achieve their full potential, both developmentally and socioeconomically’’ (1,2)].
Currently, there are still >700,000 deaths per year globally related to diarrheal diseases (3), and in addition, the frequency of diarrheal episodes has not declined but remains unacceptably high (4). Among the myriad pathogens causing diarrhea in low/middle-income countries….Read more

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