LL-37: important in host-pathogen interaction

 

MBL, Human, ELISA kit
LL-37, Human, ELISA kit
Cat. # HK321

Cathelicidins comprise a family of mammalian proteins containing a cationic antimicrobial domain. LL-37 (or CAP-18) is the human variant of this antimicrobial peptide that plays a central role in the innate immune system and is expressed by epithelial cells and leukocytes. The peptide exerts a wide spectrum of antimicrobial reactions and other biological activities. LL-37 is for example chemotactic for neutrophils, monocytes, mast cells and T-cells, but it also induces degranulation, alters transcriptional responses and stimulates vascularization and re-epithelialization. Additional defensive roles are regulating the inflammatory response, serving as a chemo-attractant for cells of the adaptive immune system and neutralizing LPS.

The first discovery of LL-37 (formerly known as FALL-39) was in the late 90ies of the last century. There still are some recent developments on the topic of cathelicidins, given that the chicken and fish analog were found one decade ago.

Historically, many papers describe the relation of LL-37 with bacterial infections, inflammation and antimicrobial activity. Recent papers show a relevance in conditions ranging from obstructive uropathy, arterial thrombosis and even dyslipidemia. Because of its relatively recent discovery it seems that the variants and the versatility of LL-37 remains to be a topic of continuous scientific discussion.

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