Short summary of Zhang, X et al; Low levels of ficolin-3 are associated with diabetic peripheral neuropathy. Acta Diabetol 2016. More information about the article can be found here.


Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes. Although a wide range of screening and diagnostic tools […] are available, there still is a lack of convenient and sensitive biomarkers. This study investigates the relation between serum ficolin-3 levels and DPN in patients with diabetes mellitus.


The study was performed with a total of 466 diabetes patients. They were tested for a variety of metabolic markers and also neuropathy was assessed. On top of this, Ficolin-3 was tested (Cat. # HK340) and compared with the diagnostic criteria that were set in this study.


Looking at the results, it was clear that the serum level of ficolin-3 in the DPN group was significantly lower than the non-DPN group. The data not only showed an implication for the DPN group, also patients with only diabetic nephropathy or only diabetic retinopathy all had significantly lower ficolin-3 levels. DPN prevalence also significantly depended on the ficolin-3 serum concentrations. Based on these results, ficolin-3 demonstrates to be an independent impact factor on the risk of DPN next to age and diabetes duration. Further studies revealing the immanent connection of ficolin-3 with the pathology of diabetic peripheral nerve disorders will provide a new prospective strategy for DPN.