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α-defensin expression associated with risk of coronary heart disease

Tuesday, May 9, 2017

Summary of Maneerat, Y et al; Increased alpha-defensin expression is associated with risk of coronary heart disease: a feasible predictive inflammatory biomarker of coronary heart disease in hyperlipidemia patients. Lipids in Health and Disease 2016. Click here for the full article.

Atherosclerosis starts as an asymptomatic but progressive condition. A combination of genetics, lifestyle and other underlying (metabolic) disorders make it a life-threatening condition causing coronary heart disease (CHD) and potentially death. Polymorphonuclear neutrophils play a pivotal role in inflammation and atherogenesis as they release human neutrophil peptides (HNP) in case of an acute coronary vascular disorder. This cross-sectional study assesses the correlation between α-defensin expression and the development of CHD. It also evaluates the predictive use of this marker for evaluating CHD risk.

HNP1-3 levels were determined in hyperlipemic patients, CHD patients and health controls using an ELISA kit (Cat. # HK317). Results demonstrated that there was a trend of increased plasma HNP1-3 in hyperlipidemia and CHD patients. Furthermore, CHD patients had higher HNP1-3 levels than hyperlipidemia patients. Based on these results, α-defensin expression has potential as an inflammatory marker for predicting CHD in hyperlipidemia patients.

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