Exposure to Helicobacter pylori infection in patients with coronary heart disease
Short summary of Matusiak, A et al; Putative consequences of exposure to Helicobacter pylori infection in patients with coronary heart disease in terms of humoral immune response and inflammation. Arch Med Sci 2016, 12(1). Full article can be found here.
Pathogens have been suggested to contribute to the development of coronary heart disease (CHD). So far there was no consensus on the role of Helicobacter pylori (Hp) infections in either causation or progression of CHD. Recently it has been shown that acute phase proteins can function as pattern recognition receptors (PRR) and are therefore potentially involved in the pathogenesis of cardiovascular disease. To create a more thorough understanding of this process, this study focuses on the exposure of CHD patients to Hp in relation to the level of serum lipopolysaccharide binding protein (LBP) as a marker of inflammation.
170 CHD patients and 58 non-CHD subjects participated in this study. All individuals were tested for H. pylori and LBP levels were also determined. The results demonstrated that CHD patients were exposed to Hp more frequently compared to the control group. The study also showed that the LBP levels were significantly higher in CHD patients and it was also related to the severity of the disease. Additionally, type I Hp strains stimulated higher LBP levels than the less pathogenic type II.
The results generated in this study support the hypothesis of a relationship between Hp infections and CHD. It also underlines the fact that high levels of LBP accelerate inflammatory processes that contribute to disease severity.