Summary of Yamashiro, K et al; Gut dysbiosis is associated with metabolism and systemic inflammation in patients with ischemic stroke. PLOS ONE 2017. Click here for the full article.

Metabolic disorders are one of the leading causes for heart disease and stroke. Increasing evidence suggests that dysbiosis is associated with metabolic diseases, but there is little known on the relation with ischemic stroke.

The aim of this study was to investigate whether the gut microbiota […] are altered in patients with ischemic stroke. Blood samples of 41 ischemic stroke patients were measured on a variety of metabolic readouts, but also cytokines and acute phase proteins were tested such as LBP (Cat. # HK315). Fecal samples were additionally used to examine the gut microbial composition with qPCR.

The results show that stroke patients had an impaired composition of the fecal bacteria and an elevated organic acid concentration. However, there were no differences in LBP concentrations, TNF-α levels and bacteremia rates between the patients with stroke and the control subjects.

Despite these findings, the data still suggests that gut dysbiosis in patients with ischemic stroke is associated with host metabolism and inflammation. Further studies are needed to determine a more predictive indicator of ischemic stroke.