Wheat sensitivity but no celiac disease, what is the cause?
Short summary of Uhde, M et al; Intestinal cell damage and systemic immune activation in individuals reporting sensitivity to wheat in the absence of coeliac disease. Full article can be found here.
Celiac disease is characterized by an immune response in the small intestine when wheat gluten are consumed. However, there remains a group of individuals that experience a range of symptoms in response to ingestion of wheat and related cereals, […] while celiac disease and IgE-mediated wheat allergy have been ruled out. Non-celiac wheat sensitivity (NCWS) is the term that is generally used to describe this condition. This paper aims to determine if sensitivity to wheat in the absence of celiac disease is associated with systemic immune activation that may be linked to an enteropathy. LBP and EndoCab® were some of the serological markers that were used to determine immune response to microbial components.
The results demonstrated that individuals with NCWS had significantly increased serum levels of LBP and Endocab® IgM, but not IgG or IgA. This while the celiac disease group had higher levels of EndoCab® IgA.
Even though the increased serum levels of the different markers demonstrate an underlying immunological response, this study does not address the potential mechanism or molecular triggers responsible for deteriorated gut integrity and microbial translocation.