Loonen, A et al; Soluble mannose receptor levels in blood correlate to disease severity in patients with community-acquired pneumonia. Immunology Letters 2018.

Community-acquired pneumonia (CAP) is the most common form of pneumonia and is a leading infectious cause worldwide. sMR, soluble mannose receptor, is a new serum marker for macrophage activation. Its extracellular domains are able to bind several ligands, like mannose, collagen and sulfated carbohydrates. Studies have shown that certain infection markers are (partly) capable to predict disease development in CAP. Since the need for new biomarkers to predict disease prognosis more precisely is still present, sMR was suggested. Results show that patients with sMR levels between 100 - 430 ng/ml had a 22.7% chance to develop severe disease, while patients with higher levels had a 33.3% chance.