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Complement factor I, Human, Natural-0
Catalog # HC2131-100UG

Complement factor I, Human, Natural

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Complement Factor I (fI) is a protein of the complement system, first isolated in guinea pig serum that regulates complement activation by cleaving cell-bound or fluid phase C3b and C4b.
Factor I deficiency in turn leads to low levels of complement component 3 (C3) in plasma, due to unregulated activation of the complement alternative pathway, and it has been associated with recurrent bacterial infections in children; more recently, mutations in the Factor I gene have been shown to be implicated in development of Haemolytic Uremic Syndrome, a renal disease also caused by unregulated complement activation.

Product type
Proteins
Amount
100 µg
Species
Human
Formulation
0.1 ml of approximately 1 mg/ml purified natural human Factor-I isolated from healthy blood donors, in Phosphate buffered saline, pH 7.2. The blood donors have been tested and found negative for various viruses (see table: Human blood test results). The exact protein concentration and functional activity is indicated on the label.
Storage and stability
Product should be stored at -70 °C. Repeated freeze and thaw cycles will cause loss of activity. The exact expiry date is indicated on the label. Use Complement factor I protein within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
Disease
Infectious diseases, Nephrology
CoA-TDS Protein
HC2131
41 kb
Safety Data Sheet
SDS - HC2131-100UG
50 kb

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