Home \ Antibodies \ Desmoglein-1, Human, mAb 27B2
Catalog # HM2113

Desmoglein-1, Human, mAb 27B2

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Desmoglein 1 is a member of the desmosomal cadherin family that comprise the desmogleins and desmocollins. Desmosomes are cell-cell junctions in most epithelial cells and serve to link the intermediate filament cytoskeletons of adjacent cells. Within the desmosome the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity. The monoclonal antibody 27B2 reacts with the 165 kDa desmoglein 1 protein. Furthermore it is not cross reactive with desmoglein 2 or desmoglein 3.

Application
Flow cytometry, Frozen sections, Immuno fluorescence, Immuno precipitation, Western blot

Use
For immuno fluorescence and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.

Product type
Monoclonal antibodies
Amount
100 µg, 20 µg
Formulation
0.2 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS, containing 0.02% sodium azide and 0.1% bovine serum albumin.
Isotype
Mouse IgG1
Species
Human
Storage and stability
Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result with the use of or derivation of this product.
Disease
Autoimmunity
Protocol
Protocol Western Blot
59 kb
Protocol SDS Page
57 kb
Protocol Immuno precipitation
54 kb
Protocol Immuno Fluorescence
39 kb
Protocol IHC-F
36 kb
CoA-TDS HM2100-HM2199
HM2113-100UG
51 kb
HM2113-20UG
51 kb
Safety Data Sheet
SDS - HM2113-100UG
52 kb
SDS - HM2113-20UG
52 kb

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