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Catalog # HM2343

Integrin alpha-IIb (CD41), Human, mAb Q90

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Monoclonal antibody Q90 recognizes human CD41, also called ITGA2B, GPIIb or integrin alpha chain 2b. It is predominantly expressed on platelets and plays a pivotal role in coagulation. CD41 associates with integrin β3 chain (GPIIa or CD61) to form the CD41/CD61 complex. This complex is a receptor for fibrinogen, vWF, fibronectin, vitronectin, thrombospondin, prothrombin and thrombospondin. The integrin receptor is required for platelet adhesion and aggregation. Per platelet there are approximately 60-80 thousand copies of the complex. CD41 has been considered a biomarker for megakaryocytes. Although there is increasing evidence that it also expressed during early hematopoiesis with low expression levels on cells with myeloid and lymphoid potential. Given its central role in haemostasis it has been considered an anti-thrombotic target with alternating success. Mutations in the genes of the CD41/CD61 complex are a cause of Glanzmann thrombasthenia leading to bleeding disorders. Furthermore, there are some associations with tumor metastasis.

Application
Frozen sections, Paraffin sections, Western blot

Application Notes
W: A reduced sample treatment and SDS-Page was used. The band size is 120 kDa.

Use
Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Product type
Monoclonal antibodies
Amount
100 µg
Formulation
0.1 ml (1 mg/ml) 0.2 μm filtered antibody solution in PBS, containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Immunogen
Synthetic CD41 peptide
Isotype
Mouse IgG1
Species
Human
Alias
ITGA2B; GP2B; ITGAB; Integrin alpha-IIb; GPalpha IIb; GPIIb; Platelet membrane glycoprotein IIb; CD41
Storage and stability
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
Disease
Cardiology and metabolism, Tumor immunology
CoA-TDS HM2300-HM2400
HM2343
56 kb

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