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Catalog # HM2388-100UG

MMP2, Human, clone 3A8-C1-E8

This antibody recognizes human metallo proteinase-2 (MMP2 or gelatinase-A)

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Monoclonal antibody HM2388 recognizes human metallo proteinase-2 (MMP2 or gelatinase-A). MMPs are a large class of zinc dependent catalytic enzymes. They cleave or degrade virtually all components of the extracellular matrix. MMPs are involved in a wide range of processes like tissue remodeling, wound healing, angiogenesis and regulation of inflammatory processes. They are also involved in pathological processes such as rheumatoid arthritis, inflammation, atherosclerosis and tumor growth and metastasis. MMPs are formed as inactive zymogens which must be cleaved to become active. Activated MMPs are inhibited by four TIMPs. TIMP and MMP expression and function are tightly regulated in order to contain a balance in proteolysis and proteolysis inhibition.
MMP2 (72Kda) is secreted as an inactive proMMP2and becomes active when captured by membrane bound MMPs. The amino-acid sequence is quite conserved (96-97%) between human, pig, rat and mouse. MMP2 has a well-known role in tumor growth, invasion and metastasis and is correlated with poor prognosis in some tumors.

Application
Immuno assays, Western blot

Application Notes
Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Product type
Monoclonal antibodies
Amount
100 µg
Formulation
0.1 ml 0.2 μm filtered in PBS+0.02%NaN3+0.5%BSA+50%glycerol
Immunogen
Purified recombinant human MMP-2 protein expressed in E.coli.
Isotype
Mouse IgG1
Species
Human
Cross reactivity
Rat – Yes
Storage and stability
Product should be stored at -20°C. Under recommended storage conditions, product is stable for at least one year.
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
CoA-TDS HM2300-HM2400
HM2388
48 kb

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