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Catalog # HP9066-1ml

C2, Human, pAb

333,00

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Glycoprotein complement factor C2 is key in the classical and lectin pathway. Its proteolytic subunit is part of as well the C3 as C5 convertase. In CP C2 is cleaved by C1s and in the LP by MASP2. C2 binds to membrane bound C4b. After cleavage C2b is released and C2a forms with C4b the C3 convertase (C4bC2a). After proteolysis of C3 into C3a and C3b, the latter fragment associates with the C4bC2a complex in order to form the C5 convertase. The formation of both convertases is crucial in complement activation and to initiate the terminal part of the cascade. Synthesis of C2 is predominantly in hepatocytes, macrophages and lung epithelial cells. Individuals with C2-deficiency appear healthy, though there are some associations with SLE, atherosclerosis and increased risk to some type of infections.

Application
Immuno assays, Immuno precipitation, Western blot

Application Notes
IA: The antibody can be used as detection antibody.
W: A non-reduced and reduced sample treatment was used. The effective dilution was 4000x - 8000x.

Use
Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions.

Product type
Polyclonal antibodies
Quantity
1 ml
Formulation
0.2 μm filtered in PBS, containing 0.09% sodium azide
Isotype
Goat Ig
Species
Human
Alias
Complement component C2
Storage and stability
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
Disease
Autoimmunity, Infectious diseases, Nephrology
CoA-TDS pAb
HP9066
57 kb

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