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Catalog # HP9072

IL-12B p40, Human, pAb

Antibody directed against the interleukin 12 (IL-12) subunit IL12B.

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This polyclonal antibody is directed against the interleukin 12 (IL-12) subunit IL12B. IL-12 is a key immunoregulatory cytokine that coordinates innate and adaptive immune responses. IL12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit IL12B, and a 35 kD subunit IL12A. IL12 is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. It acts on T and natural killer cells, and has a broad array of biological activities. The main role of IL-12 is activation of Interferon gamma ( IFN-gamma) production by triggering the Jak-STAT signaling pathway. Overexpression of the IL12 gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. IL-12 is also linked to autoimmunity. Promoter polymorphisms in the IL12 gene have been reported to be associated with the severity of atopic and non-atopic asthma in children.

Immuno assays, Paraffin sections, Western blot

Application Notes
Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Product type
Polyclonal antibodies
100 µg
0.1 ml (1 mg/ml) 0.2 μm filtered in PBS+0.02%NaN3+50%glycerol
Synthetic peptide, human IL-12B p40
Rabbit Ig
Storage and stability
Product should be stored at -20°C. Under recommended storage conditions, product is stable for at least one year.
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
48 kb

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