Home \ Antibodies \ IL-22, Human, pAb
Catalog # HP9073

IL-22, Human, pAb

This antibody recognizes IL-22, key regulator of immunity and inflammation at the mucosal surface.

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IL22 is a key regulator of immunity and inflammation at the mucosal surface. It is produced by cells from the innate and adaptive immune system, like ILCs, γδT-cells, NK, TH1,17&22 cells. The latter are together with ILC3s the main source of IL-22. IL-22 is considered as a non-inflammatory cytokine and show similarities with IL-10. ILC3s are present in large numbers in mucosal layers and do not require antigen recognition for their activation. In barrier organs the mucosal layer is constantly in contact with the environment and needs to adapt to this continuously trigger by microbes and their metabolites in order to prevent acute inflammation. Thereby IL-22 has important functions in host defense and tissue repair. IL-22 provides protective innate immunity in the absence of an adaptive response. IL-22 signals via heterodimeric receptor complex (IL-22R1&2) expressed on epithelial cells of the lung, gut, skin, liver, pancreas and kidneys. It is not expressed by hematopoietic cells. Another mechanism of IL-22 to control pathogens is by aiding the binding of complement C3 to the bacteria. Furthermore IL22 increases C3 expression in the liver. IL-22 binding protein exists in humans as a soluble form of IL-22 receptor. Binding to the receptor results primarily in JAK/STAT downstream signaling IL-22 induces expression of chemokines like CXCL1&5 and stimulates the expression of antimicrobial peptides such as beta-defensins, S100 peptides and calprotectin. Elevated levels of this IL-22 has been seen in chronic inflammatory diseases such as psoriasis, rheumatoid arthritis and some lung diseases. The antibody is cross reactive to mouse and rat IL-22.

Application
Immuno assays, Western blot

Application Notes
Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Product type
Polyclonal antibodies
Quantity
100 µg
Formulation
0.1 ml 0.2 μm filtered in PBS+0.02%NaN3+0.5%BSA+50%glycerol
Immunogen
Synthetic peptide, human IL-22
Isotype
Rabbit Ig
Species
Human
Cross reactivity
Mouse – Yes, Rat – Yes
Storage and stability
Product should be stored at -20°C. Under recommended storage conditions, product is stable for at least one year.
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
CoA-TDS pAb
HP9073
68 kb

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