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Catalog # HP9074

IL-33, Human, pAb

This antibody recognizes IL-33: IL-33 has been identified as alarmin with a dual function

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IL-33 has been identified as alarmin with a dual function; an IL-1 family cytokine acting extracellularly and intracellularly as nuclear factor regulating gene expression. IL-33 is released to alert the immune system as a first line of defense. It is expressed and released after cell injury to initiate an immune response and to start repair processes by epithelial cells after damage as a result of an inflammatory process. IL-33 activates many immune cells including ILC2, mast cells, eosinophils, basophils, DCs and Th2 cells. This explains the direct relation to allergic inflammation. Besides, IL-33 is implicated infectious diseases like pathogenic infection, cardiovascular disease, IBD and diabetes. IL-33 signals via ST2 (suppression of tumorigenesis 2), a member of the Toll-like/IL1 receptor (TIR domain containing) superfamily. There are 2 forms of ST2 receptor, membrane bound and a soluble form that acts as a decoy receptor. Via IL33/ST2 activation ILC2 cells produce Th2 cytokines such as IL-5&-13. Intracellularly, IL-33 functions as transcriptional repressor of NF-κB mediated gene expression. This makes it an inhibitor of pro-inflammatory signaling.

Immuno assays, Paraffin sections, Western blot

Application Notes
Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Product type
Polyclonal antibodies
100 µg
0.1 ml 0.2 μm filtered in PBS+0.02%NaN3+0.5%BSA+50%glycerol
Synthetic peptide, human IL-33
Rabbit Ig
Cross reactivity
Mouse – Yes, Rat – Yes
Storage and stability
Product should be stored at -20°C. Under recommended storage conditions, product is stable for at least one year.
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
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