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Catalog # HM2396

Mucin-1, Human, clone HMFG2

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Monoclonal antibody clone HMFG2 recognizes human mucin-1 (Muc1). Mucins are high-molecular mass glycoproteins with peptide repeat domains and a dense O-glycosylation. Mucus is a biological hydrogel covering epithelial surfaces, including the eyes, lungs, stomach and reproductive system. If functions as a barrier to mucosal pathogens and to prevent damage from mechanical forces. Mucins consist of a family of over 20 members of which muc1 is one of most extensive studied member. MUC1 consists of a large, extracellular, O-glycosylated polypeptide backbone that extends 200–500 nm above the apical surface; a transmembrane domain that can be cleaved and enables shedding of the extracellular domain; and a cytoplasmic tail capable of signaling. Muc1 is involved diverse cellular responses including cell proliferation, growth, differentiation, migration, invasion, survival and secretion of growth factors, and cytokines being considered as a molecular sensor and signal transductor. Furthermore, MUC1 has been demonstrated to play a dynamic role in protection of the host from infection by a wide variety of pathogens and to regulate inflammatory responses to infection. This role is modulated via the inflammasome receptors. Besides its role in cancer, altered MUC1 expression levels and glycosylation patterns have also been associated with patients with inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease.

Application
Flow cytometry, Frozen sections, Functional studies, Immuno assays, Paraffin sections, Western blot

Application Notes
• FC: Extracellulair staining was used with antibody HMFG2.
• W: Reduced and non-reduced can be used. The expected band sizes are 75 and 120kDa.

Product type
Monoclonal antibodies
Quantity
20 µg, 100 µg
Formulation
0.2 µm filtered in PBS+0.1%BSA
Immunogen
Synthetic peptide from cytoplasmic tail of human MUC1 protein
Isotype
Mouse IgG1
Species
Human
Alias
MUC-1, Breast carcinoma-associated antigen DF3, Cancer antigen 15-3, CA 15-3, Carcinoma-associated mucin, Episialin, H23AG, Krebs von den Lungen-6, KL-6, PEMT, Peanut-reactive urinary mucin, PUM, Polymorphic epithelial mucin, PEM, Tumor-associated epithelial membrane antigen, EMA, Tumor-associated mucin, CD227
Storage and stability
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
CoA-TDS HM2300-HM2400

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