Home \ Antibodies \ Punctin-1, Human, mAb 1B2-8-14
Catalog # HM2194

Punctin-1, Human, mAb 1B2-8-14


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Monoclonal antibody 1B2-8-14 reacts with Punctin-1 (ADAMTSL-1). Punctin-1 is a secreted molecule
resembling members of the family of proteases designated ADAMTS (a disintegrin-like and
metalloprotease domain with thrombospondin type I motif). ADAMTS proteases are secreted enzymes that
consist of a metalloprotease domain (which provides the catalytic activity) and ancillary domains (which
provide substrate, cell or extracellular matrix activity). Punctin-1 lacks the pro-metalloprotease and the
disintegrin-like domain typical of this family but contains other ADAMTS domains in precise order including
4 thrombospondin-I repeats. Punctin-1 is an extracellular matrix protein in tissues and deposited into the
cell substratum and localized towards the periphery of transfected cells. Punctin-1 and Punctin-2
(ADAMTSL-3) are the first members of a novel family of ADAMTS-like proteins that appear to have
important functions in the extracellular matrix.
Monoclonal antibody 1B2-8-14 recognizes the spacer domain and reacts with molecular species of 55 kDa
or a doublet of 55 kDa and 60 kDa (glycosylated form). Note that proteolysis of Punctin-1 has been
described and additional smaller bands may also be obtained.

Immuno assays, Western blot

For Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions.

Product type
Monoclonal antibodies
20 µg, 100 µg
0.2 ml (100 µ/ml) 0.2 µm filtered antibody solution in PBS containing 0.1% bovine serum albumin and 0.02% sodium azide.
Mouse IgG2b
Storage and stability
Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result with the use of or derivation of this product.
Cardiology and metabolism

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