Home \ Antibodies \ Tissue factor, Human, mAb CLB/TF-5
Catalog # HM2346

Tissue factor, Human, mAb CLB/TF-5

120,00333,00

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The monoclonal antibody clone CLB/TF-5 recognize human soluble tissue factor (also known as coagulation factor III, tissue thromboplastin or CD142). This protein activates the blood clotting system by binding to, and activating, the plasma serine protease, factor VIIa, following vascular injury. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Because of its essential role in hemostasis, tissue factor plays a role in pathology associated with hemostasis, triggering the coagulation system in many thrombotic diseases and the coagulopathies associated with sepsis and other forms of disseminated intravascular coagulation. Recent research has also implicated tissue factor in a variety of nonhemostatic roles, including cell signaling, inflammation, vasculogenesis, and tumor growth and metastasis.

Application
Flow cytometry, Immuno assays, Western blot

Application Notes
FC: Antibody CLB/TFPI C-Terminus stains the extracellular domain of TFPI.
W: A reduced sample treatment and SDS-Page was used. Human serum and plasma was used and bands of ~50 and 26kDa were found.

Use
Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions.

Product type
Monoclonal antibodies
Quantity
20 µg, 100 µg
Formulation
1 ml (100 μg/ml) 0.2 μm filtered protein A purified antibody solution in 20 mM TRIS, 150 mM NaCL, pH 8.0.
Isotype
Mouse IgG1
Species
Human
Alias
Coagulation factor III, CD142, Thromboplastin
Storage and stability
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
Disease
Cardiology and metabolism, Tumor immunology
CoA-TDS HM2300-HM2400
HM2346
85 kb

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