Home \ Antibodies \ TLR2, Human, mAb TL2.3, FITC
Catalog # HM2066F

TLR2, Human, mAb TL2.3, FITC

120,00394,00

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Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila, toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. TLR2 has been identified as a receptor that is central to the innate immune response to lipoproteins of Gram-negative bacteria, several whole Gram-positive bacteria, as well as a receptor for peptidoglycan and lipoteichoic acid and other bacterial cell membrane products. A functional interaction between TLR2 and TLR6 in the cellular response to various bacterial products has been discovered. The currently accepted paradigm regards TLR2 as an essential receptor for many eubacterial cell wall components, including lipoproteins and peptidoglycan. Bacterial species as diverse as mycobacteria, spirochetes, mycoplasma, Staphylococcus aureus, and Streptococcus pneumoniae have all been shown to mediate cellular activation via TLR2 (CD282).
The FITC conjugated monoclonal antibody TL2.3 is specific for human TLR2 (CD282). TL2.3 is useful for studies on the role of TLR2 as a pattern recognition receptor in microbial products induced cytokine production by TLR2 bearing cells such as human peripheral blood mononuclear cells.
The human Toll-like receptor 2 (TLR2) is Patent protected by US Patent no. US 7,071,310. License rights on the Patent are acquired from Leiv Eriksson Nukaping AS, Norway. Hycult Biotech is not responsible for any patent infringements that might result with the use or derivation of this product.

Application
Flow cytometry, Frozen sections, Functional studies, Immuno assays, Immuno fluorescence, Western blot

Use
Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Positive Control
THP-1 cells

Product type
Monoclonal antibodies
Quantity
20 µg, 100 µg
Formulation
0.2 ml (100 μg/ml) 0.2 μm filtered protein G purified FITC conjugated antibody solution in PBS, containing 1% bovine serum albumin and 0.02% sodium azide.
Conjugate
FITC
Immunogen
Human TLR2-expressing CHO cells
Isotype
Mouse IgG2a
Species
Human
Cross reactivity
Canine – Yes
Alias
Toll-like receptor 2, Toll/interleukin-1 receptor-like protein 4, CD282<br> - Gene name: TLR2, TIL4
Storage and stability
Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.
Disease
Infectious diseases

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