TLR10, Human, mAb 3C10C5
Catalog #: HM2302
Quantity: 100 µg
The monoclonal antibody 3C10C5 reacts with human TLR-10, which is a type I transmembrane glycoprotein that consist of an extracellular domain, a single transmembrane segment and a cytoplasmic Toll/interleukin (IL)-1 receptor domain and has an apparent molecular mass of approximately 94kDa. In total humans possess 10 TLR family members (1–10). The TLR 10, 1, and 6 genes are tandemly arranged and seem to have arisen from duplication events. In accordance with their role in host defense, monocytes/macrophages express most TLRs, whereas the expression of individual TLRs in dendritic cells depends upon their subtype. The microbial agonists for TLRs include a wide variety of structures such as nucleic acids from bacteria and viruses, as well as outer membrane components of bacteria, fungi, and protozoan organisms. Despite extensive research on the TLRs, human TLR10 has remained an orphan receptor without a known agonist or function. Although recent studies have shown that the putative ligands include di- and triacetylated lipopeptides as can be found in bacteria. Variations in the TLR10 gene have been associated with several diseases such as papillary thyroid carcinoma, urothelial bladder cancer, and Crohn’s disease. The monocalonal antibody 3C10C5 is suitable for immunoassay and flow cytometry.
|Product type||Monoclonal antibodies|
|Formulation||1 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide.|
|Immunogen||The extracellular domain of TLR10|
|Storage and stability||Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.|
|Precautions||For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product.|
Application Notes:FC: 3C10C5 stains the extracellular domain of human TLR10.
Use:For Immuno assays and flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.