Oxidative stress

Oxidative stress is involved in many human diseases, such as atherosclerosis, Parkinson’s disease and Alzheimer’s disease. In addition, it is assumed to be important in ageing. However, reactive oxygen species can also be beneficial, as they are used by the immune system to attack and kill pathogens. Detection or measurement of oxidation markers is helpful to assess oxidant activity and to monitor the effectiveness of the antioxidant system. Superoxides and other free radicals contribute, together with many other factors like inflammation, radiation, and carcinogen exposure, to DNA damage. Antibodies and assays for detection of DNA adducts, such as ethenoadenosine, BPDE-DNA, and 8-oxoguanine, are valuable markers for studies on DNA damage. Nitrotyrosine has been identified as a marker of inflammation and production of NO. Various pathways including the formation of peroxynitrite lead to nitrotyrosine production. Since nitrotyrosine is a stable end product of peroxynitrite oxidation, assessment of its plasma concentration is a useful marker of NO-dependent damage in vivo, taking into account that most proteins have a longer half life in the circulation than nitrite/nitrate (NOX). Nitrotyrosine has been detected by immunohistology in various inflammatory processes, including atherosclerotic plaques, celiac disease, rheumatoid arthritis, chronic renal failure and septic shock.
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  1. Oxidized phospholipids, Mouse, clone 10C12
    100 µg
    FS IA P W
    HM1142-100UG
  2. MPO, Human, pAb
    20 µg
    F IA P
    HP9048-20UG
  3. Chlorotyrosine, pAb
    20 µg
    F IA P
    HP5002-20UG
  4. MG-H1, mAb 1H7G5
    20 µg
    IA IF W
    HM5017-20UG
  5. Halotyrosine, mAb BTK-94C
    20 µg
    IA IF IP W
    HM5016-20UG
  6. MGO-modified proteins, Human, mAb MGO-1
    20 µg
    IA P W
    HM5014-20UG
  7. CML, Human, mAb CML26
    20 µg
    F IA IF P W
    HM5013-20UG
  8. BPDE, mAb 8E11
    20 µg
    IA
    HM5008-20UG
  9. BPDE-DNA, mAb 5D11
    20 µg
    FC IA IF IP P
    HM5007-20UG
  10. Ethenoadenosine, mAb 1G4
    20 µg
    FC F IA IP W
    HM5005-20UG
  11. Nitrotyrosine, mAb HM.11
    20 µg
    F IA P W
    HM5001-20UG
  12. MPO, Rat, mAb B7
    20 µg
    FC F IA W
    HM3039-20UG
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Abbreviation legend

F Frozen sections
FC Flow cytometry
FS Functional studies
IA Immuno assays
IF Immuno fluorescence
IP Immuno precipitation
P Paraffin sections
W Western blot

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