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TLR and inflammasome

Toll like receptors (TLRs) are a class of non-catalytic receptors that function as pattern recognition receptors (PRRs). These receptors recognize pathogen-associated molecular patterns (PAMPs) that are shared by large groups of microorganisms, but also endogenous alarm signals, like apoptosis related membrane fragments and inflammatory ligands. Common cytoplasmic domains allow TLRs to use the same signaling molecules used by the interleukin-1 receptors (IL-1Rs), including MyD88 and TRIF. In man both intracellular and extracellular TLR exist. The intracellularly located TLR9 confers responses to bacterial DNA via species-specific CpG-motif recognition. Therefore, CpG-DNA can be used to investigate TLR9 response in various systems.
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Product description Price Quantity Applications Catalog #  
CpG-B DNA (ODN 2006), Human/ Mouse
$369.00
200 nmol FS HC4039

Lipopolysaccharide (LPS) from E.coli, Serotype J5 (Rc)
$213.00
1 mg FS HC4047

TLR2, Human, mAb TLR2.45, FITC
$398.00
100 µg FC IF IP HM2220F

TLR4 agonist set: Lipopolysaccharide (LPS) from Salmonella minnesota
$596.00
2x 0.5 mg and 2x 0.25 mg FS HC4063

CpG-DNA, Mouse
$369.00
200 nmol FS HC4033

Non CpG-DNA, Human/Mouse
$369.00
200 nmol HC4034

CpG-A DNA (ODN 2216), Human/Mouse
$369.00
200 nmol FS HC4037

CpG-B DNA, Rabbit
$369.00
200 nmol HC4038

CpG-B DNA, Rat
$369.00
200 nmol FS HC4040

CpG-C DNA (ODN 2395), Human/ Mouse
$369.00
200 nmol HC4041

Non CpG-DNA, Rabbit
$369.00
200 nmol HC4042

Lipopolysaccharide (LPS) from E.coli Serotype O55:B5
$213.00
1 mg FS HC4045

Lipopolysaccharide (LPS) from E.coli, Serotype EH100 (Ra)
$213.00
1 mg FS HC4046

Lipopolysaccharide (LPS) from E.coli, Serotype R515 (Re)
$213.00
1 mg FS HC4048

Lipid A from E.coli, Serotype R515 (Re)
$238.00
1 mg FS HC4049

Monosphosphoryl Lipid A (MPL-A) from E.coli, R515 (Re)
$238.00
0.5 mg FS HC4050

Lipopolysaccharide (LPS) from Salmonella minnesota, S-form
$213.00
1 mg FS HC4051

Lipopolysaccharide (LPS) from Salmonella minnesota, R60 (Ra)
$213.00
1 mg FS HC4052

Lipopolysaccharide (LPS) from Salmonella minnesota, R345 (Rb)
$213.00
1 mg FS HC4053

Lipopolysaccharide (LPS) from Salmonella minnesota, R5 (Rc)
$213.00
1 mg FS HC4054

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Abbreviation legend
  • F Frozen sections
  • IF Immuno fluorescence
  • FC Flow cytometry
  • IP Immuno precipitation
  • FS Functional studies
  • P Paraffin sections
  • IA Immuno assays
  • W Western blot
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