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TLR and inflammasome
Toll like receptors (TLRs) are a class of non-catalytic receptors that function as pattern recognition receptors (PRRs). These receptors recognize pathogen-associated molecular patterns (PAMPs) that are shared by large groups of microorganisms, but also endogenous alarm signals, like apoptosis related membrane fragments and inflammatory ligands. Common cytoplasmic domains allow TLRs to use the same signaling molecules used by the interleukin-1 receptors (IL-1Rs), including MyD88 and TRIF. In man both intracellular and extracellular TLR exist. The intracellularly located TLR9 confers responses to bacterial DNA via species-specific CpG-motif recognition. Therefore, CpG-DNA can be used to investigate TLR9 response in various systems.
Product description
Quantity
Applications
Catalog #
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100 µgF FC FS IF IPHM1029
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100 µgF FC FS IF IPHM1029F
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0.5 mgF FC FS IF IPHM1029-FS
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50 µgF FC FS IPHM1030
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100 µgF FC IA P WHM1042
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100 µgF FC IA P WHM1042F
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100 µgF FC IF IPHM1047F
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100 µgF FC FS IA IF IP WHM1049
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100 µgF FC FS IA IF IPHM1054
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100 µgF FC FS IA IF IPHM1054F
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0.5 mgF FC FS IA IF IPHM1054-FS
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100 µgF FC IA IP PHM1058
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100 µgF FC IA IP PHM1058F
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100 testsF FC IA IP PHM1058PE-100
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25 testsF FC IA IP PHM1058PE-25
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50 µgF FCHM1059
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100 µgF FC FS IA PHM1092
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100 µgF FC FS WHM2056
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0.5 mgF FC FS WHM2056-FS
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50 µgF FC FS WHM2057
Abbreviation legend
F Frozen sections
FC Flow cytometry
FS Functional studies
IA Immuno assays
IF Immuno fluorescence
IP Immuno precipitation
P Paraffin sections
W Western blot
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