Coagulation molecules

Both pro- and anticoagulant pathways are involved in inflammation and in many inflammatory diseases. The protein C anticoagulant pathway serves as a major system for controlling thrombosis, limiting inflammatory responses, and potentially decreasing endothelial cell apoptosis in response to inflammatory cytokines. The essential components of this pathway include thrombin, thrombomodulin, the endothelial cell protein C receptor (EPCR), protein C and protein S. Life-threatening coagulation disorders, such as thrombotic thrombocytopenic purpura (TTP) often arise from deficiency or inhibition of the enzyme ADAMTS-13.

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Abbreviation legend

F Frozen sections
FC Flow cytometry
FS Functional studies
IA Immuno assays
IF Immuno fluorescence
IP Immuno precipitation
P Paraffin sections
W Western blot

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