C5L2, Human, Peptide
Catalog #: HC2103
Quantity: 10 µg
The orphan receptor C5L2 (also known as gpr77), which shares 35% amino identity with CD88, is a promiscuous complement fragment-binding protein. C5L2 binds C5a with high affinity. It has a 10-fold higher affinity for C5a desArg than CD88. C5L2 also has an affinity for C4a and C3a, and their metabolites C4a desArg and C3a desArg. C3a binds at a side distinct from the C5a binding site. Unlike other chemoattractant receptors C5L2 couples poorly to the intracellular signalling and internalisation machinery. The human C5L2 peptide is a N-terminal peptide (1-23).
|Formulation||Lyophilized product in PBS containing 10 µg human C5L2. Reconstitute the vial by pipetting 0.1 ml distilled or de-ionised water (Caution: vial is under vacuum).|
|Storage and stability||Lyophilized product should be stored at 4°C. Store stock solution after reconstitution in aliquots at -20°C. Repeated freeze and thaw cycles cause loss of activity. Under recommended storage conditions, product is stable for one year.|
|Precautions||For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result with the use of or derivation of this product.|
|Disease||Infectious diseases, Nephrology|
Use:For dilutions use protein stabilized phosphate buffered saline, pH 7.4.
Huber-Lang, M et al; Changes in the novel orphan, C5a Receptor (C5L2), during experimental sepsis and sepsis in humans. J Immunol 2005, 174: 1104