RNase 7: an epithelial marker

RNase 7, Human, ELISA kit
RNase 7, Human, ELISA kit
Cat. # HK371
 
RNase 7, a member of the RNase A superfamily, is a type of nuclease that catalyzes the degradation of RNA into smaller components. It plays a critical role in many biological processes and is expressed in various somatic tissues such as the skin, respiratory tract, urinary tract and the gut. Studies have revealed its broad spectrum antimicrobial activity against many pathogenic microorganisms and a remarkably potent activity against the vancomycin-resistant Enterococcus faecium. Even though RNase 7 has been first described in a paper from 1962, scientific publications describing the role and function of this protein really only started from 2000 onwards.
 
RNase 7 expression is associated mainly with skin-related conditions, such as atopic dermatitis, skin infection (S. aureus) and acne inversa. In addition it has also demonstrated to play an important role in conditions involving the epithelial barriers, such as urinary tract infection and allergic rhinitis.
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