Soluble mannose receptor in critical and chronic conditions

 

sMR, Human, ELISA kit
sMR, Human, ELISA kit
Cat. # HK381
 

The mannose receptor (also known as CD206) is a C-type lectin that is expressed on cell membranes of macrophages and functions as a pattern recognition receptor (PRR). Even though the exact role of the mannose receptor is unknown, it has demonstrated to have a role in both the innate and adaptive immune response as it modulates TLR4 signaling. Besides this it is responsible for a variety of immunological functions such as inducing cytokine production and regulation of the inflammatory process.

Measuring the soluble form of the mannose receptor (sMR) is considered a novel marker and has already demonstrated diagnostic potential for a variety of conditions as it may reflect the activation state of tissue macrophages. Elevated levels of sMR for example has shown to correlate with chronic conditions such as liver fibrosis and hepatitis B. Additionally, sMR also appears to be related to disease activity in patients with rheumatoid arthritis. Beside chronic conditions, there are also insights that reveal its usefulness as an acute marker in conditions such as sepsis, critical illness and infectious disease.

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