Serum ficolin-3: potential to be a good prognostic predictive biomarker after head trauma

Short summary of Pan, J et al; Low serum ficolin-3 levels are associated with severity and poor outcome in traumatic brain injury. Journal of Neuroinflammation (2015) 12:226

In recent years, the application of biomarkers identified in the peripheral blood has shown potential clinical utility in neurointensive care as diagnostic, prognostic, and monitoring adjuncts. Evidence from experimental, clinical, and in vitro studies highlights an important role for ficolinmediated activation of the lectin pathway of complement in contributing to inflammation within the injured brain.

Compared with the healthy controls, serum ficolin-3 levels on admission were statistically decreased in patients with severe traumatic brain injury. Ficolin-3 was also identified as an independent prognostic predictor for 1-week mortality,6-month mortality, and 6-month unfavorable outcome. 


Graph showing change of serum ficolin-3 levels after severe traumatic brain injury