Home \ Antibodies \ IL-6, Mouse, mAb MP5-20F3
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Catalog # HM1004

IL-6, Mouse, mAb MP5-20F3

120,00774,00

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The antibody neutralizes mouse interleukin 6 (IL-6). It does not cross-react with LPS (the component of the
bacterial cell wall which is considered responsible for the toxicity of gram-negative bacteria) and TNFalpha
nor does it bind to either human or rat IL-6. The antibody inhibits IL-6 induced proliferation of the B9
assay. IL-6 is a pluripotent 20-22 kDa cytokine which plays a role in the pathophysiology of severe
infection and regulates the immune response, acute phase reaction and haematopoiesis. IL-6 plays a
critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and
myeloma. Continuous IL-6 gene expression makes an essential contribution to a multistep oncogenesis of
plasma cell neoplasia. IL-6 is a very useful culture supplement for the generation of a high number of
antibody-producing hybridomas.

Application
Functional studies, Immuno assays, Immuno precipitation

Application Notes
The antibody can be used for in vitro and in vivo inhibition of activity of IL-6. Furthermore the antibody is useful for immunochemical investigations of mouse IL-6 in structural studies and for quantitative/qualitative immunochemical detection methods. This antibody may be used as a coating antibody in immuno assay procedures.

Use
For neutralisation of biological activity dilutions have to be made according to the amount of IL-6 to be inactivated.

Product type
Monoclonal antibodies
Quantity
20 µg, 100 µg, 500 µg
Formulation
Quantities >500 µg will be send without preservative and carrier free. Quantities <500 µg will be send with preservative and carrier. exact formulation can be found on the datasheet.
Isotype
Rat IgG1
Species
Mouse
Storage and stability
Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
Precautions
For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result with the use of or derivation of this product.
Disease
Autoimmunity, Tumor immunology

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