
IL-6, Mouse, mAb MP5-20F3
The antibody neutralizes mouse interleukin 6 (IL-6). It does not cross-react with LPS (the component of the
bacterial cell wall which is considered responsible for the toxicity of gram-negative bacteria) and TNFalpha
nor does it bind to either human or rat IL-6. The antibody inhibits IL-6 induced proliferation of the B9
assay. IL-6 is a pluripotent 20-22 kDa cytokine which plays a role in the pathophysiology of severe
infection and regulates the immune response, acute phase reaction and haematopoiesis. IL-6 plays a
critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and
myeloma. Continuous IL-6 gene expression makes an essential contribution to a multistep oncogenesis of
plasma cell neoplasia. IL-6 is a very useful culture supplement for the generation of a high number of
antibody-producing hybridomas.
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Latest Hycult Biotech news
- New Human Complement Pathway AssaysWe are very proud of our newly developed human classical and alternative complement pathway assays. They are produced in response to a growing demand for quantitative investigation of complement inhibitors or regulators at lower sample dilutions. This development aims to address the issue of false negative results, enabling more accurate and reliable analysis of complement… Read more: New Human Complement Pathway Assays
- Navigating the pitfalls in complement analysisOur colleague Erik Toonen shared his experience on how to analyze complement at the Complement-based Drug Development Summit in Boston in September 11-13th, 2023. He showed valuable insights on analyzing complements. For accurate complement analysis, it is important that not only the correct technique is used but also that pre-analytical sample handling is performed in… Read more: Navigating the pitfalls in complement analysis
- NEW Human C3d ELISAWe are happy to introduce our new ELISA (cat.# HK3017) designed to detect human C3d. What sets this assay apart is its utilization of a distinctive neo-epitope capture antibody that selectively targets a specific C3d region of the alpha chain, which is not available in other C3 variants. This way it specifically distinguishes C3d from native C3… Read more: NEW Human C3d ELISA