IL-6, Mouse, mAb MP5-20F3

The antibody neutralizes mouse interleukin 6 (IL-6). It does not cross-react with LPS (the component of the
bacterial cell wall which is considered responsible for the toxicity of gram-negative bacteria) and TNFalpha
nor does it bind to either human or rat IL-6. The antibody inhibits IL-6 induced proliferation of the B9
assay. IL-6 is a pluripotent 20-22 kDa cytokine which plays a role in the pathophysiology of severe
infection and regulates the immune response, acute phase reaction and haematopoiesis. IL-6 plays a
critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and
myeloma. Continuous IL-6 gene expression makes an essential contribution to a multistep oncogenesis of
plasma cell neoplasia. IL-6 is a very useful culture supplement for the generation of a high number of
antibody-producing hybridomas.